SAMbinder S-adenosyl-L-methionine (SAM) is one of the essential metabolic cofactor/intermediate which is found in almost every cellular life forms and enzymes. It plays a vital role in various metabolic and regulatory pathways, mainly involved in transfer of various groups (e.g., methyl, aminopropyl, methylene). It is a second widely studied ligand after ATP. SAM is a potential drug target for many diseases such as cancer, Alzheimer’s, Parkinson, Epilepsy, Osrteoarthritis and many more. Some of the reported drug targets are Catechol O-methyltransferase, Glycine N-methyltransferase, S-adenosylmethionine synthase isoform type-1, S-adenosylmethionine decarboxylase proenzyme, Cystathionine beta-synthase.
SAMbinder Major Features Sequence based module:This module predict SAM binding residues in a protein from its promary sequence. PSSM based Module: This module utilize evolutionary information (in form of PSSM profile) of a protein to predict SAM binding residues in a protein. Peptide Mapping: This server allow user to predict SAM binding residues in a protein by mapping known peptides that contains SAM interacting central residue. Standalone Software: It has been developed using Python and will be freely available to users. Datasets: All datasets used in this study will be available to public. More about SAM S-adenosyl-L-methionine (SAM; SAMe; AdoMet) is an important molecule which plays an important role in various cellular reactions and metabolic pathways.......
A picture of Ustad Alladiya Khan, the establisher of this gharana.
The gharan established by Ustad Alladiya Khan has given indian classical world a battery of accomplished artists - Kesarbai Kerkar, Mogubai Kurdikar, Dhondu Tai Kulkarni, Kishori Amonkar, Ashwini Bhide-Deshpande etc.
Here are a few ragas sung by stalwarts from Jaipur Atrauli Gharana which I like the most: Raga Bageshri by Kishori Amonkar Bada Khyal is the tradition Kaun Gat Bhayi set to madhyalaya teental
Chota Khyal is Aeri Maai Sajan Nahi Aaye set to madhyalaya Addha, a specialty of Tai.
Although the feeling of sadness and separation is the signature of Bageshree and is very well presented in this repertoire, this Bageshree presents a new face of Bageshree. The harkats, refrains are just heavenly. No one could have thought of such beautiful permutations of Bageshree swaras. I am speechless after listening to this perfection. Notice how within the first 2 minutes (with only her swarmandal playing for more than 30 seconds), this doyenne of classical music sets up the mood of Bageshri. This Bageshri is sung by younger Kishori Tai, somewhere around when she made swarmandal her accompaniment.
Raga Basanti Kedar by Mallikarjun Mansur and Kesarbai Kerkar As elaborated by Dr.......